{"signature": "0xfe7602881f4ac433eb1cf3289cdacb1422c0e9f08412e2bb97dd87718108eb6b13ffd2b7be5935d76537dfa67b6c2b5c14ae8d9b6b60c11cdfde2ff159f1eb211b", "application": {"round": "0x6e8dc2e623204d61b0e59e668702654ae336c9f7", "answers": [{"type": "email", "hidden": true, "question": "Email Address (for us to share updates and contact you directly)", "questionId": 0, "encryptedAnswer": {"ciphertext": "X4iXt/maeZIairGB6lYFU136aOBaJyNHY5gpcTNwo7wK2V3zzpg1Ghhf16T0hlDG", "encryptedSymmetricKey": "9257d774b1982dee82f858effed7786edca11cac8968c75d2755bf02484adc1b08e605b6c7ca08124bb61c92d39e3c1917840e028f8b7dfeba69b36f113532d472ac6f989009cafed27f5ffc6b11401587ea21957dfb3e5caa99d7f2ea2896808c96a4d8ecb1fa6d4af2b35b745de2d1ff825906219baeb6ddf2ebd8aeaa058f00000000000000206090b3939910d115ae42279256cfe374cf5f9455b24f79e4f326b2f9863e476d8194780372448b9292a8158de7b76997"}}, {"type": "short-answer", "hidden": true, "question": "Telegram username", "questionId": 1, "encryptedAnswer": {"ciphertext": "5rjWPCfhEtXi7Qchp8430rOeDXqggorY4nej549UVjY=", "encryptedSymmetricKey": "c207dcc68ad174829c10eb7f61c253db8d4e6efaffc6633bf00b76936c3f698ad40c5b5d3f50fd5d640c21d2bff46c00c90220df65d82bb397c3c74d50a3a0e6d44e4a0833c4e2e64792ba9c299795f7021b69601e29fd516121bade4d07db937dfb9426f4c728109454c948b4749521abeed2e3c3e9f1deeb788e21c0825e57000000000000002061ed8c6138d4c8d3579fb2159eef917c348b1ab3b78fffad102577332eb7f7bc2bddbfb635d0714a709fc55d58cfaa81"}}, {"type": "multiple-choice", "answer": "Yes", "hidden": true, "question": "Have you read and confirmed your project abides by the Program General Eligibility Policy? https://gitcoin.notion.site/Gitcoin-Grants-Beta-Round-Eligibility-b7fca9fd3c26450b89ded11caaa6497f", "questionId": 2}, {"type": "short-answer", "answer": "GitCoin Longevity round at the end of 2021 (approx. 70K DAI)", "hidden": false, "question": "Previous project funding sources (VC, grants, token sales, etc)", "questionId": 3}, {"type": "number", "answer": "70000", "hidden": false, "question": "Total prior funding for project in USD", "questionId": 4}, {"type": "number", "answer": "7", "hidden": false, "question": "Number of team members", "questionId": 5}, {"type": "paragraph", "answer": "https://www.linkedin.com/in/olga-borysova-79390884/ \nhttps://github.com/winternewt \nhttps://github.com/marfantyk\n( https://github.com/Alex-Karmazin , https://www.linkedin.com/in/alex-karmazin-ua/)\n( https://github.com/nikhilYadala , https://www.linkedin.com/in/nikhilyadala/ )\nhttps://github.com/lnalinaf ", "hidden": false, "question": "Profiles or socials of other main team members publicly associated with project", "questionId": 6}, {"type": "number", "answer": "44", "hidden": false, "question": "How old is the project? (Months)", "questionId": 7}, {"type": "paragraph", "answer": "Just DNA-Seq ( http://dna-seq.github.io/ ) is a suite of open-source libraries and pipelines aimed at empowering individuals to take control of their own genetic information. The goal for 2023 round is to make it decentralized (allowing decentralized workflow execution and storage), interactive (to answer their questions about their results),  actionable (to help them use their genomic data in their lifespan interventions), easier to understand (we started developing Hack-Your-Own-Genome massive online course). If we collect the amount of funding similar to the previous time, we envision 1.5 years timeline.", "hidden": true, "question": "Describe your project in a few paragraphs (ideally including a problem statement, solution, roadmap, and timeline for implementation)", "questionId": 8}, {"type": "paragraph", "answer": "Our project democratizes personalized genomics. It allows everybody to analyze their genome in a transparent, open-source privacy-preserving explainable way, investigate (with reports and also manually, with UI) whatever they are interested in, and contribute their knowledge by extending or adding a genomics module. A vast amount of genomic knowledge is accumulated in the literature, but people cannot just take the genetic findings from research papers to annotate their genome; we build a bridge to make it happen.", "hidden": true, "question": "How does your project support the mission or goals of DeSci?", "questionId": 9}, {"type": "paragraph", "answer": "60 percent of the funding will be used to compensate developers, scientists, designers, and other team members for their work,  10 percent will be spent compensating the work of external collaborators, 15 percent will be spent on outreach (conferences, courses, etc.),  while around 15 percent will be spent on infrastructure (including computations and indexing of more longevity and genomics papers with GPT embeddings).", "hidden": false, "question": "Describe how funds from the grants program will be used for your project.", "questionId": 10}, {"type": "address", "hidden": true, "question": "If you participated in past grant rounds (i.e. DeSci GR15) using a different project payout wallet address, please share it here.", "questionId": 11, "encryptedAnswer": {"ciphertext": "JmtsUB3/P5gCBwAqLzpUHYRqPtkzGDLV6URvr805c/I=", "encryptedSymmetricKey": "835aadff07d5eb2a74eb6141d5b901b6c5418b654c3dcd1e81ccf5c200ebca608f2ebd3326985e98fbe8456cee720c169327ba35e9035a35ba379702c254ba76787499f9f727506b401fe03f9b6f1650dff1a5f23c5ce281dcb0faa0d46a908adbb3279dc14ade5e9a5dd294ab08fa73b008bfb249dc9b0075f91bc0a9bd360a0000000000000020b242dc54cecfcc3b64baee2101c7e101d355f652a9f200fcbad545669f46d46bb1eb7a8c4b3ee30e81dc7ea5f3d0198c"}}, {"type": "paragraph", "answer": "The project was initially funded by GitCoin during the longevity funding round (end of 2021), we have successfully delivered on most of our promises: with 23 source code repositories ( see https://github.com/dna-seq ), 11 published Oak Var modules, several hack-your-own-genome workshops together with documentation and scientific research paper (last one is yet in a draft stage).", "hidden": false, "question": "If this project participated in past grant rounds, please share any new updates or milestones since the last round.", "questionId": 12}, {"type": "paragraph", "answer": "We were thinking about using the multi-signature wallet to democratize funds management. However, GitCoin had a massive number of bugs with multi-sig wallets in the past that blocked people from getting matching, so we decided to go with regular metamask.", "hidden": false, "question": "Is there any other information you would like to share about your project, previous work, other project affiliations, or potential conflicts of interest? (or anything not covered elsewhere in this application that you feel is relevant to share)", "questionId": 13}, {"type": "multiple-choice", "hidden": true, "question": "Does 50% of your team reflect the diversity of the community your project serves with a particular emphasis on including women, Black, Indigenous, and People of Color (BIPoC), individuals with disabilities, and members of the LGBTQ+ community?", "questionId": 14, "encryptedAnswer": {"ciphertext": "ioulmjaIAk40RrDH9WZF2DcDgvKf172bYXs7Hn4C9YE=", "encryptedSymmetricKey": "e6a40821648099ebac39ac84ca671328f4e80fba4765bb61411d1c75262ed4548e931227036e1d29951f24e12e640d0cffbaddbaee1dff4902d3716c579ffdb0a020802b7d4257a689a8c4185adb3fd44df0100e61e306d3312c7cfe2d49bb834697a690dc63144e590c7b70c7a42622117eaafc37f9d4bd9b1857db04f1368e000000000000002043658ba5f318e86f804e3728776383c3784b6abfd1e5629720e3b27a63d8e4eb5ebf47f41891cc0141e6e23d258ecdb4"}}], "project": {"id": "10:0x8e1bD5Da87C14dd8e08F7ecc2aBf9D1d558ea174:127", "title": "Just-DNA-Seq", "logoImg": "bafkreia3ei7wli3sstfcpwgivps4hmdeph6hdwwiio5jqvm765ae3wfuju", "metaPtr": {"pointer": "bafkreid3cebljbgacxewajxraequm6k4la7ghime4phhw5wer4ugkmuq7q", "protocol": "1"}, "website": "https://dna-seq.github.io", "bannerImg": "bafkreiciyiho4d6xaxfuyo7zwn2xx6dd2332f2rqan3p5obwczmd74uoee", "createdAt": 1681763994346, "userGithub": "antonkulaga", "credentials": {}, "description": "Just DNA-Seq: Achieving and Expanding Our Vision with Web3 and Decentralization\n\nJust DNA-Seq ( http://dna-seq.github.io/ ) is a suite of open-source libraries and pipelines to empower individuals to take control of their genetic information. Initially funded by GitCoin during the longevity funding round (end of 2021), we have successfully delivered on most of our promises: with 23 source code repositories ( see https://github.com/dna-seq ), 11 published Oak Var modules, several hack-your-own-genome workshops together with documentation and scientific research paper (yet, in a draft stage).\n\nNow, we are excited to make our project:\n* More decentralized - by incorporating Web3 and decentralization elements to further enhance its accessibility and utility by integrating our pipeline with PLEX ( https://docs.labdao.xyz/#about-plex ) developed by LabDAO ( https://labdao.xyz/ ) and allowing our Oakvar modules to run in a secure privacy-preserving DNA vault (collaboration with Genomes DAO).\n* More interactive - we have already developed a prototype of the chatbot called LongevityGPT that utilizes large language models to answer (with verifiable references to avoid hallucinations of the model) users' questions about Longevity. We want to extend it to answer users' questions about genetic and genetic variants, including (if users allow) questions about her own genetic variations. Of course, it cannot compare in accuracy/robustness with personalized genomics consultants, but it should significantly improve understanding of the results by non-professionals.\n* More actionable - at the moment, so-called \u201caging clocks\u201d are used to measure the individual pace of aging, which are based on blood, methylation, glycosylation, and other parameters, and are used to correct lifespan interventions. However, non of them take into account patient genetics, so we want to investigate if our longevity scores can improve the aging clocks' accuracy. This project is done in collaboration with Healome; the proposal has recently been approved by UK biobank, which will provide the data.\n* Easier to understand - we started developing \u201cHack your own genome\u201d Massive Online Course to bring personalized genomics to more people. We will also work more with the user community to improve the overall user experience and robustness of the platform.\n\nWe invite the Gitcoin community to join us in this endeavor!\n\nWhat you can already do with our existing codebase:\n1) Realign your raw genome reads and perform variant calling using state-of-the-art tools and bioinformatics pipelines.\n2) Annotate your own genome with the longevity-focused OakVar plugin, which also includes:\n* Known longevity and cancer risks\n* Known drug interactions\n* Cardio hereditary disease risks\n* Coronary artery disease risk variations\n3) Receive a comprehensive and transparent open-source report featuring all the above information, as well as polygenic health risk predictions and personalized recommendations related to longevity. You can check out an example of such a report (computed from the genome of one of the project founders) is https://dna-seq.github.io/report_example/\n\nYou can deploy everything mentioned above on your laptop. You can also try our development server at http://agingkills.eu:8081/index.html , where you can either upload your data (note: as it is a development version, use at your own risk!) or use our demo account (login: jdnaseq@gmail.com, password: 123456) to explore already processed open-source genomes and generated reports.\n\n\nWhy Just DNA-Seq?\n\nThe first human genome sequencing project concluded on April 14, 2003, after more than 12 years of labor and costing approximately $3 billion. Since then, genome sequencing has become widely accessible and affordable, with commercial offerings priced between $400-$800. However, these services often lack transparency, privacy, and customization.\nJust DNA-Seq was born out of our team's passion for addressing these shortcomings. We recognized that commercial genetic testing services often rely on proprietary databases and algorithms, which limit users' understanding of the predictions they receive. Additionally, we identified a lack of commercial offerings for longevity-related predictions, despite the growing interest in this area.\nAs a result, we developed Just DNA-Seq to harness the wealth of information generously shared by the scientific community through open-source solutions.\n\nOn decentralization and privacy:\n\nAt the Longevity round, we focused on our core features and science done right. However, our results lack the scale and degrees of freedom decentralization provides. Right now, you either deploy everything on your hardware or somebody runs a centralized server for you (you can also play with our development server, but we do not provide guarantees).\n\nWe want to remove that restriction and enable personalized genomics for everybody, including users with limited time, hardware (esp. RAM), or technical skill and expertise. For this, we partner with Lab DAO ( https://labdao.xyz/ ) to enable the running of our scientific workflows on a decentralized infrastructure with the PLEx Lab Exchange platform. It offers an opportunity to close a gap between invested DIY enthusiasts who can deploy and maintain computational nodes for tokenized compensation and the average Joe who only want the results delivered and does not want to dive in deep.\n\nWe also partner with Genomics DAO ( https://genomes.io/ ) to allow running our OakVar modules inside secure privacy-preserving DNA vaults. \n\nWe need this funding round to finish those developments and extend our longevity reports with new data that emerged since our first Gitcoin funding round.", "lastUpdated": 0, "projectGithub": "dna-seq", "projectTwitter": "just_dna_seq"}, "recipient": "0xBc7BeB2d44Eb0Cddf6c0F2560a21475c2E2aC19C"}}