{"signature": "0x94166bcd289d35452c6f51391d200b8eb9edd59606f8b88b376fd8eb86ce118d10d8984d4d221192cd6a5477aeb69f7d46a6a209d3bf950e8f40e9fb6a9416721c", "application": {"round": "0x6e8dc2e623204d61b0e59e668702654ae336c9f7", "answers": [{"type": "email", "hidden": true, "question": "Email Address (for us to share updates and contact you directly)", "questionId": 0, "encryptedAnswer": {"ciphertext": "bcSmg1PaOtyKETPC7ZrwZwxwgtWUoopj2VQQGpoZwtWQ+MCMipbo5qnRQSxxlmqz", "encryptedSymmetricKey": "d6a5120ed8fbb0e80f200a7ce888b5ed6caecdb9051391501f3afb5bcf437a5c7870702bc5772b8d235ea58f949b81118038423e49e6a6a76dce5e852bbe21cd603c4dec4c5065a99bb53b67b9e7260b51a78dc501d2d3be65ac0015fafb41b7fdc02acd97e3f2be47607ba2d7191451333f13c9e8b4d4e22cbeb48569c5131f0000000000000020b8c5535c8a49c4df2f1db9022f7bdd48ec413762eaf745de3eb285581ebf0adb89f1785bbedf5fcc9411d0305260e0a4"}}, {"type": "short-answer", "hidden": true, "question": "Telegram username", "questionId": 1, "encryptedAnswer": {"ciphertext": "Qzy4HonPIXXM2azs4Nh+yxj/zle0nzaohkTdh5oJSrw=", "encryptedSymmetricKey": "7aca80b5b788b2fec6b7edad615f3a2374a4ed0fa530479155ab73535d97f2fe2b2aa20ba2a7ab97b7170b5fab07a6035605a297fbaa504d4dcbbef97511e2dac83934abab4832cfbd9a457853b36e91195e4cf1c018f90f2d1cf483ff22cfb078421a0cb1937ee23ab8d4d555f6ad746f72a3f1dc38fefae4ad825b6ab7210300000000000000203c346c1d36b5024fa987d04ec18c6f475056599d961848d7ba51899ad032659f8ae63bac1f181d37b5612578a5053eab"}}, {"type": "multiple-choice", "answer": "Yes", "hidden": true, "question": "Have you read and confirmed your project abides by the Program General Eligibility Policy? https://gitcoin.notion.site/Gitcoin-Grants-Beta-Round-Eligibility-b7fca9fd3c26450b89ded11caaa6497f", "questionId": 2}, {"type": "short-answer", "answer": "Previous Gitcoin Rounds", "hidden": false, "question": "Previous project funding sources (VC, grants, token sales, etc)", "questionId": 3}, {"type": "number", "answer": "17000", "hidden": false, "question": "Total prior funding for project in USD", "questionId": 4}, {"type": "number", "answer": "5", "hidden": false, "question": "Number of team members", "questionId": 5}, {"type": "paragraph", "answer": "https://twitter.com/keithcomito\nhttps://twitter.com/olivermedvedik\nhttps://www.linkedin.com/in/ryan-m-50531a77/\nhttps://twitter.com/sdainow", "hidden": false, "question": "Profiles or socials of other main team members publicly associated with project", "questionId": 6}, {"type": "number", "answer": "18", "hidden": false, "question": "How old is the project? (Months)", "questionId": 7}, {"type": "paragraph", "answer": "We are building a headset to test promising research showing light and sound of certain frequencies may remediate symptoms of dementia, with the aim of producing an inexpensive deployment unit to be used in a forthcoming decentralized clinical trial in humans. ", "hidden": true, "question": "Describe your project in a few paragraphs (ideally including a problem statement, solution, roadmap, and timeline for implementation)", "questionId": 8}, {"type": "paragraph", "answer": "If successful this project will be the first example of a truly decentralized clinical trial, testing non-drug interventions for Alzheimer's disease. Furthermore, if  the result of this project yields a therapy which can remediate such diseases in any way, it will be a landmark moment for decentralized science - demonstrating that the crowd can accomplish a goal of immense public good which the traditional system has been unable to accomplish with over a trillion dollars in tax-payer funding over 30 years, and catalyzing significant changes toward decentralization within existing clinical trials infrastructure. ", "hidden": true, "question": "How does your project support the mission or goals of DeSci?", "questionId": 9}, {"type": "paragraph", "answer": "Funding will allow us to build on our promising preclinical human participant findings to develop a hardware/software system that is able to iteratively apply various stimulus combinations, and zero in, based on EEG biofeedback, on optimal configurations at an individual patient level.", "hidden": false, "question": "Describe how funds from the grants program will be used for your project.", "questionId": 10}, {"type": "address", "hidden": true, "question": "If you participated in past grant rounds (i.e. DeSci GR15) using a different project payout wallet address, please share it here.", "questionId": 11, "encryptedAnswer": {"ciphertext": "WmGKix8RPro5IdJGh+tfgV2KAtmdOfW6Mb96hmV/FSM=", "encryptedSymmetricKey": "db96cc81385d59f4d60d2bed6db86ccf84db2efaac02b0205bb5152c172d27e3de615cf60748e51e9002f2cde5b3f715de24e415bac199ae189cbc0ae8974bf68a6868e5a7e3b9ef5db70b3bd4a289efd0adabd3896be462ace95a4d90d1b9a89b49debdb9cb01dd38171c1d3a1e50cf8fbb1baa570df734a59005f2ec905891000000000000002037f18336e9a312609f96e4f570cb358cac1d3bcdf0b2a733d44e52917f79db02ab8ce4268e39f3d243235baabef5c1af"}}, {"type": "paragraph", "answer": "We have gathered promising preclinical human participant results and have successfully developed patented technology which enabled a new paradigm of patient-specific stimulation. This equips us to move forward and structure a decentralized clinical trial to test for therapeutic benefit of our approach. ", "hidden": false, "question": "If this project participated in past grant rounds, please share any new updates or milestones since the last round.", "questionId": 12}, {"type": "paragraph", "answer": "Our work at Lifespan.io to address the root causes of aging is incredibly vital to the current and future success of humanity, and the effect of a positive result with a project such as this would be tremendous in shifting public perception and priorities towards decentralized science and overcoming all age-related disease. Our team members are well known and respected, and if anyone would like to learn more please look us up and Lifespan.io as well. Thank you!", "hidden": false, "question": "Is there any other information you would like to share about your project, previous work, other project affiliations, or potential conflicts of interest? (or anything not covered elsewhere in this application that you feel is relevant to share)", "questionId": 13}, {"type": "multiple-choice", "hidden": true, "question": "Does 50% of your team reflect the diversity of the community your project serves with a particular emphasis on including women, Black, Indigenous, and People of Color (BIPoC), individuals with disabilities, and members of the LGBTQ+ community?", "questionId": 14, "encryptedAnswer": {"ciphertext": "dkqY52fDpZj6RpQgSP/atonNLSTFtgf8VMWJseAj+rc=", "encryptedSymmetricKey": "19c0e5c158c996d5ff2419c51eb2a4f3fb8ec563b9b0d2cb3af6b02716bed9629e86642943d55ec544a96c23c9bac502d34a97c58f76820abd06ff83d114257b8d026e50d0539890965fcf32e4300d1d05a32a6e7d6d7365aedb7061dee2f8b02a9b38e175f6ffc68475a916545917e0689d2f23fcf67af9568d84907474ccbe0000000000000020324ad8b9394c49d5d140c710c55674687d298e9eb0380332a6065a287054c10f38fb743e12858d3bc5d1af2ece86a985"}}], "project": {"id": "10:0x8e1bD5Da87C14dd8e08F7ecc2aBf9D1d558ea174:246", "title": "Stopping Alzheimer's with Light and Sound", "logoImg": "bafkreih3arbfspi2ww7up444kjrwgyowwlvaxtaw536f4ooqm6iaseheyq", "metaPtr": {"pointer": "bafkreif6fbkcju2n3t5c2s32czcc5v3zl34bzpmlqrepozkirb44jmog5a", "protocol": "1"}, "website": "https://www.lifespan.io/the-mindset-project/", "bannerImg": "bafkreiakpfgvcuwyq5addbdhe6wokw53a2sa425spsdsisvmtlnspvdcdq", "createdAt": 1682058048056, "userGithub": "KeithComito", "credentials": {"twitter": {"type": ["VerifiableCredential"], "proof": {"jws": "eyJhbGciOiJFZERTQSIsImNyaXQiOlsiYjY0Il0sImI2NCI6ZmFsc2V9..hyvwuTXoZ7XwGYP-_jRLU4IFvuQIdsl7eaToaM19Ci_4yXwHq479INuRTN_NgL9KWAAJfdRJoS_KFwaT0BN1Cg", "type": "Ed25519Signature2018", "created": "2023-04-21T06:13:19.341Z", "proofPurpose": "assertionMethod", "verificationMethod": "did:key:z6MkghvGHLobLEdj1bgRLhS4LPGJAvbMA1tn2zcRyqmYU5LC#z6MkghvGHLobLEdj1bgRLhS4LPGJAvbMA1tn2zcRyqmYU5LC"}, "issuer": "did:key:z6MkghvGHLobLEdj1bgRLhS4LPGJAvbMA1tn2zcRyqmYU5LC", "@context": ["https://www.w3.org/2018/credentials/v1"], "issuanceDate": "2023-04-21T06:13:19.341Z", "expirationDate": "2023-07-20T06:13:19.341Z", "credentialSubject": {"id": "did:pkh:eip155:1:0xa51E0a99B53d5B00937a2631d5865468A3543B7d", "hash": "v0.0.0:AXoiDvrIN28ntOb9HJVbq0wXvyHAZtkzY2eiL3E/6t0=", "@context": [{"hash": "https://schema.org/Text", "provider": "https://schema.org/Text"}], "provider": "ClearTextTwitter#LifespanIO"}}}, "description": "## Launching a First-In-Kind Decentralized Clinical Trial, Testing Non-Drug Interventions for Alzheimer's.\n\nThe search for an effective **pharmacological (drug based) therapeutic for dementia**, particularly those stemming from **Alzheimer\u2019s Disease (AD)**, is ongoing, expensive and, to date, has been fraught with **multiple dead ends**. Despite this bleak outlook, we have **strong evidence** to suggest that **present day technology** can be effectively organized to develop a **promising therapy to defeat Alzheimer's Disease.**\n  \n**[Watch the video below](https://vimeo.com/750458841/779478118e)**\n**[![IMAGE ALT TEXT](https://i.vimeocdn.com/video/1508827312-3ae4178ba675e6410f6aba969e0e45b3c83d863c5734d0d64068e05093373704-d?mw=1280&mh=720&q=70)](https://vimeo.com/750458841/779478118e \"MindSet Project Description Video\")**\n\n***New For Gitcoin Beta Round!***\n\nThanks to **your contributions in GR15** we have built a hardware / software **system demonstrating verifiable neurological effects** based on applied stimuli, for which we have successfully attained a non-provisional **[patent](https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/11612757?fbclid=IwAR0DsCUzpGIC6jljPKItCfeQNJCEPCuJSddVTAaFPK2xfCisY1LP1_piUiY)**. Using this **we have generated preliminary human data** showing effective and modifiable neural entrainment in humans. If you can **help us in this round** we will be able to acquire the equipment we need to **build an inexpensive and scalable prototype** capable of administering a first-in-kind truly **decentralized clinical trial**, to have therapies reach everyone as soon as possible.\n\n![Dr. Oliver Medvedik administers visual and audio stimuli to himself and his mother, Irena](https://c.gitcoin.co/docs/2f2f39c5b519d74095647cba7ac82d75/MindSet-Love.jpg)\n\n## Project Details\n\n***Evidence for Effectiveness***\n\nPublished scientific **evidence strongly supports** the development of **treatments for Alzheimer's disease that are non-pharmacological in nature**. Evidence also suggests that **multiple** such non-pharmacological interventions (NPIs) **can act in concert**, thereby increasing the effectiveness of such therapies in delaying and even reversing AD. Despite these positive developments, **traditional clinical trials** for NPIs have only been done on a relatively **small scale** and testing for efficacy has been mostly performed at clinical centers using standard paper-based assessment tests. This has been mainly due to the **complexity in administering** an NPI based treatment in a traditional clinical setting.\n\nWe are thankful to our **amazing team of advisors** for supporting us in this work, including renowned neuroscientist **Dr. Heather Berlin**, and renowned biologists **Drs. George Church and Brian Kennedy**.\n\n**[Watch the video below](https://youtu.be/Pn_J-f1-8dg)**\n**[![IMAGE ALT TEXT](https://img.youtube.com/vi/Pn_J-f1-8dg/maxresdefault.jpg)](https://youtu.be/Pn_J-f1-8dg \"Can Music Fight a Real Life Vecna? Stranger Things Running Up That Hill Explained - Science Blast\")**\n\n***The PIA MindSet***\n\nWe are developing a therapeutic device, the **PIA MindSet**, that incorporates **multiple NPI interventions that are safe and have shown promise** in both animal testing and **in human clinical trials**. This **headset c**ould be directly marketed and sold to users, where they themselves would **directly participate** in operating the device and submitting data for analysis. This would **circumvent the slow and costly route** towards usage and testing that would normally occur through an FDA approved clinical trial setting. Furthermore, the device may **also be used by healthy users** as a potential means towards **cognitive enhancement**.\n  \n***IRENA: an Individually Recorded, Enhanced Neurological Assessment software suite***\n\nIn conjunction, we propose developing an online individually recorded, enhanced **neurological assessment testing** tool, **IRENA**, where individual user parameters, arising from headset usage, along with online cognitive assessments, will be uploaded and **analyzed in real time** by the user base. This would vastly enhance our ability to assess and **improve the therapeutic value** of the **PIA MindSet**. **IRENA** would give us the capability to 1) **gauge efficacy** on a vastly larger scale of participants than traditional paper-based assessment tests have done thus far 2) **rapidly assess** the efficacy of various parameters of the **PIA MindSet** in real-time and 3) more **precisely identify** which users are receiving the most therapeutic **benefits**, i.e. those suffering from mild cognitive impairment (MCI) versus more extreme forms of dementia.\n\n![MindSet Project Components Diagram](https://c.gitcoin.co/docs/400c161dbe0e5bfae83fd2500b4ae154/MindSet-Diagram.jpg)\n\n***Project Development***\n\nTo launch the development of the **PIA MindSet** and **IRENA** software, we need to establish an initial **team of dedicated**, full time **software developers**, **hardware prototype fabricators**, along with a team lead that would direct all areas of operation. To these ends, it may be useful to break down the Project into three main working groups: **Interventions, Assessment and Analytics**. Each will require their own particular skill sets to achieve a minimal viable product success for the overall Project. There will be considerable overlap with each working group of course, for example, **validating primary scientific literature** regarding assessment tests and interventions. The **Interventions group** would focus on designing and building a device that incorporates several interventions. Also **developing the protocols for self-administering** the interventions. Manufacturing and distribution will also be a key component of this **working group**.\n\nThe **Assessment group** would focus on **software for the cognitive test**. This will require assessing scientific literature and either using and adopting available cognitive tests, such as **MiniCog**, and/or developing **news test** that would function on either an iOS/Android **smartphone**, **tablet** and/or **computer** workstation. Another key goal of the assessments group is to have **protocols** in place that would **mimic a trial study** with controls and experimental groups that would be the best fit for this type of **self administered device**. Development of the \u201ctrial protocol\u201d itself may involve considerable overlap with members' expertise among all three working groups. \n\nThe **Analytics group** will need to determine the best way to **securely store and manage the** **data** arriving from the self-assessment test (**IRENA**) and determine the best analytical tools to apply to tease out positive outcomes. This will help determine not only **which multi-intervention combinations are effective**, but also enable us to **determine the minimal numbers of participants required to revisit any promising intervention** **for any future** follow-up studies in a more traditional **\u201cgold standard\u201d** double-blinded **clinical trial**. If this approach works, it would have the **profound effect of upending how standard clinical trials are designed** in the future.\n\n***How Your Support Will Help Us Fight Alzheimer\u2019s Disease***\n  \n**Your contributions** will allow us to bring on additional **team members** and hasten the **completion of our prototype**, and \u2014 if it is successful \u2014 also help us make the resulting therapeutic hardware and software as **affordable and easy to use as possible**. Doing so will allow it to be **maximally available to the public**, and tee-up the ability to perform a **first-in-kind decentralized clinical trial** proving remediation of **Alzhiemer\u2019s**.\n\n  \n\nSuch an outcome would be **incredible** not only for the patients themselves, but also for their **loved ones** and all of society, due to mitigating the vast **socio-economic** harm caused by such diseases.\n\nFurthermore, **finally showing real progress** against these diseases will go a **long way towards convincing the public** that we are at last in the game in terms of fighting age-related diseases generally, and help usher in a new age of **support for healthy human longevity**. Together we can do this.\n\n### Thank You!", "lastUpdated": 0, "projectTwitter": "LifespanIO"}, "recipient": "0xF8dBc69F9657EF4928539BB8bdae7D9a9191f286"}}