{"signature": "0x4dbc3b0b060ad7935956ce390364b57f0188aa0ebc2b3f2e7ffb5a3b636edd282009a30d6d7c3cf0919d21fd08e8d1891b070102fd93d691f8463e7617e385421b", "application": {"round": "0x6e8dc2e623204d61b0e59e668702654ae336c9f7", "answers": [{"type": "email", "hidden": true, "question": "Email Address (for us to share updates and contact you directly)", "questionId": 0, "encryptedAnswer": {"ciphertext": "PRhGclPkXfXAamTskiIfNVlvGmmfT1yF+N9r9kW7ONOlM/RfTs25Q6qYbzyh71k9", "encryptedSymmetricKey": "1f3e532fb35d4b1c73907066b0cdb71873d8a7b84c59fa4b311a2f1d243afc5c4cca4d7cb331ddae7239d6dcbd8814136331b088ff2d7cab96db5d1d020b56cc911d7c199f88d3846c614f0b09679cdc4200b530f70f792626776cd5c1d745a2b949a5804ea7e810d78949699d5305518e38422fcf845810a2249fa1671a3f7900000000000000204503584dad88a1dd267ebabaf9ba67345b043b7339e9f48a397a5a2146bc4f293ee7cbb05c81fcd004f750f20a9c10a6"}}, {"type": "short-answer", "hidden": true, "question": "Telegram username", "questionId": 1, "encryptedAnswer": {"ciphertext": "gxP6fWc2VknrD7+qjYbHZJcsPwCIU+jFnbguP4NF1l9dy9R3WJS3d1Xc4ec6tz5i", "encryptedSymmetricKey": "4e5a74695ff507d505650177f01aa714fe213e3b6ee7660185e55f5fffd422d25e75a9cf09b43c22fc97d36859c43e13b9885b7b14cd8519abe869dd59d31fab8de7f2369fdfad615b8ee8eb770caa3b607cec41883ee1b89c0cf1f6eb40ea9368cc35284ecc1c0d218c1b4e6db28e4eda94381868d2e87124ad3049dfcb1e440000000000000020d916118fb20f124225674e91741e1e206edc8bfbdf1d58d96433668c7b7832237e937eaacb82a197f1b96713a95bc894"}}, {"type": "multiple-choice", "answer": "Yes", "hidden": true, "question": "Have you read and confirmed your project abides by the Program General Eligibility Policy? https://gitcoin.notion.site/Gitcoin-Grants-Beta-Round-Eligibility-b7fca9fd3c26450b89ded11caaa6497f", "questionId": 2}, {"type": "short-answer", "answer": "Gitcoin Grants", "hidden": false, "question": "Previous project funding sources (VC, grants, token sales, etc)", "questionId": 3}, {"type": "number", "answer": "11000", "hidden": false, "question": "Total prior funding for project in USD", "questionId": 4}, {"type": "number", "answer": "4", "hidden": false, "question": "Number of team members", "questionId": 5}, {"type": "paragraph", "answer": "Savva Kerdemelidis, Founder & CEO, https://www.linkedin.com/in/savvak/\n\nZan Lowe-Skillern, BD & Partnerships, https://www.linkedin.com/in/zanloweskillern/\n\nDr Jason Cross, Strategic Advisor, https://www.linkedin.com/in/crossjasonm/\n\nAndrew Horton, CIO, https://www.linkedin.com/in/andrewhortonsecurity/, https://github.com/urbanadventurer\n\nBrahma P. Sen, Blockchain Developer, https://github.com/brahmapsen, https://www.linkedin.com/in/brahma-p-sen-06a2593/\n\nZack West, Web/Front End Developer, https://www.linkedin.com/in/alphazwest/\n\nNick Fiorenza, BD & Operations, https://www.linkedin.com/in/nicholascharlesfiorenza/\n\nCyrus of Eden, Web3 Architect, https://www.linkedin.com/in/knouroozi/", "hidden": false, "question": "Profiles or socials of other main team members publicly associated with project", "questionId": 6}, {"type": "number", "answer": "24", "hidden": false, "question": "How old is the project? (Months)", "questionId": 7}, {"type": "paragraph", "answer": "Currently, 1000s of otherwise viable unmonopolizable therapies are ignored by the pharmaceutical industry because a monopoly price cannot be enforced. We call them public good medicines because once the treatment protocol is published, it is not possible to stop people accessing the therapy from multiple sources (non-excludable) and use of the treatment protocol does not prevent others from using it (non-rivalrous). \n\nUnfortunately, this causes a tragedy of the commons which means that pharma companies will not fund the large clinical trials needed for them to be reimbursed by health insurers or obtain regulatory approval. Governments and health insurers also do not want to take on the political risk of paying for large clinical trials in case they fail, which means these treatments will typically not be accepted by the mainstream medical establishment. They include repurposed off-patent generic drugs, supplements, plant medicines, psychedelics, diets, and non-pharmaceutical / lifestyle interventions.\n\nWe can solve this tragedy of the commons and provide a high impact use case for web3 that unlocks billions of dollars in social value for relatively low cost by establishing an Impact Market that incentivises impact investors to fund IP-NFTs representing public good medicines. Successful clinical trial data that validates the safety and efficacy of such public good medicines converts the IP-NFTs into Hypercerts eligible to receive outcome payments from a crowdfunded Open Source Medical Prize Fund proportional to improved patient outcomes validated in clinical trials. The Impact Market also de-risks the funding of clinical trials for donors / public. The result would be that investors fund new public good medicines that are off-patent, unmonopolizable, and available to the entire global community at low cost, while obtaining a standard return on investment. \n\nHowever, in order to bring this open source business model to pharma, we need to crowdfund a source of retroactive (and quadratic) funding of the Impact Market through a Medical Prize Fund. Together,  the community can usher in a new era of medicine which does not ignore otherwise viable therapies because they are not profitable under the traditional patent system. Unlike donations to traditional charities (which often receive the majority of their funding from big pharma), through this novel \u201cpay-for-success\u201d mechanism, you can also be sure that your donations will only fund successful clinical trials.\n\nOur current goal is to engage with healthcare payers to support the establishment of a Medical Prize Fund that can act as a source of retroactive public goods funding for open source medicines. \n\n", "hidden": true, "question": "Describe your project in a few paragraphs (ideally including a problem statement, solution, roadmap, and timeline for implementation)", "questionId": 8}, {"type": "paragraph", "answer": "Medical researchers want to develop new medicines to help patients. However, on one side, they are stuck with competitive grant funding which is highly centralised and on the other side, they can only develop new medicines if they can be monopolised using patents. Crowd Funded Cures is developing the infrastructure to support a new way: Pay-For-Success contracts or Medical Prizes can reward the publication of clinical trial data for low-cost therapies that could provide billions of dollars in social value for relatively low cost. This Impact Market can be mediated using IP-NFTs and Hypercerts framework. ", "hidden": true, "question": "How does your project support the mission or goals of DeSci?", "questionId": 9}, {"type": "paragraph", "answer": "Crowd Funded Cures wishes to use this funding to conduct a retrospective clinical study to help obtain backing of a pilot prospective interventional pharmacoeconomic randomised controlled trial (IVPE RCT) from a payer, a form of de-risked PFS contract using payer cost saving to fund low-cost / off-patent therapies, before the end of 2023. We also intend to continue fundraising for our Generic Drug Repurposing LongevityPrize.com and Open Psychedelic Medical Prize for depression. \n\nThis pilot will create a revenue model to build core web3 rails including blockchain-based storage of clinical trial data with our partner Rymedi. ", "hidden": false, "question": "Describe how funds from the grants program will be used for your project.", "questionId": 10}, {"type": "address", "hidden": true, "question": "If you participated in past grant rounds (i.e. DeSci GR15) using a different project payout wallet address, please share it here.", "questionId": 11, "encryptedAnswer": {"ciphertext": "8xY9rPM3U4B9E8gZignli1eX8LSUebgEMU8zkE86ZPQ=", "encryptedSymmetricKey": "e18627b352f1c898cf372c5397360031ee87e37afae637afe4f2c6897c282528fbed4d55b538bd8c9fc3ebb1558b32109f7b0da6dd5f53fcaf323e6ff23ac1a8b3acec0d6ca942228e7d2b2aac1e1f92aefa9166b3f96d136fe3aa60dadc1b98a677a9db4d5863ba9b495d4d2fded15e319d351e1683ea06c2e8a693c46d4ace00000000000000208b687130581d0ce8f95c84f151a08592104f4880b734a3aa84719906f22f6cd493f472af144d459640419b3626980e85"}}, {"type": "paragraph", "answer": "Since the last round, our Web3 Architect Cryus has built a Proof of Concept Streaming Medical Prize Fund Protocol toward integrating Radicle V1 drips for streaming of funds and Hypercerts / IP-NFT integration for allowing prospective funding of Open Source medicines:\n\nhttps://github.com/edendao/love-cures\n\nProtocol Labs research seminar with a demo of the Medical Prize Fund protocol:\n\nhttps://www.youtube.com/watch?v=IQZlAtUx728\n\nWe have also partnered with Rymedi, which are a patient engagement tool using blockchain for storage and auditing of real-world-evidence. \n\nWe have been engaging with various payers (govt and private) to support a pay-for-success contract and use of interventional pharmacoeconomics to fund development of low-cost therapies using payer cost savings and are on track to get backing for a pilot by the end of 2023. ", "hidden": false, "question": "If this project participated in past grant rounds, please share any new updates or milestones since the last round.", "questionId": 12}, {"type": "paragraph", "answer": "", "hidden": false, "question": "Is there any other information you would like to share about your project, previous work, other project affiliations, or potential conflicts of interest? (or anything not covered elsewhere in this application that you feel is relevant to share)", "questionId": 13}, {"type": "multiple-choice", "hidden": true, "question": "Does 50% of your team reflect the diversity of the community your project serves with a particular emphasis on including women, Black, Indigenous, and People of Color (BIPoC), individuals with disabilities, and members of the LGBTQ+ community?", "questionId": 14, "encryptedAnswer": {"ciphertext": "hpqcwRsdX+ROU1FUAQYXmpVmu+qyzaDx6bs9vVeytDo=", "encryptedSymmetricKey": "fe25fc018e45413d9dad7d94cc7f8e7aac10c6b3c7165a4c2e87fff297914e2459ec89e23e667e5d984b0304695ed61574cb0e63e109198856cdec3a4bb96b197cc9a4fa649c719d5e39f090805dd79a3472ea4152f5b783938ba68c95231a87356a155abb24a1a328a94afadc67fbeb30dd23c9755ab35cf83e67eddc1585210000000000000020abe441dae9920789109acbda413e9d26e14275006e5966977e892691f540c79901875d9eb058f505177f67cce6817c87"}}], "project": {"id": "1:0x03506eD3f57892C85DB20C36846e9c808aFe9ef4:468", "title": "Crowd Funded Cures", "logoImg": "bafkreidkuzj6dp3ruvfxlrkdces2rwig4k3zjdfnyj6cjkqerhgo74sj2u", "metaPtr": {"pointer": "bafkreih6wge2w63jy24legpodufh5rrbm6tbgcoijplhoo4tjahjkelyoy", "protocol": "1"}, "website": "https://crowdfundedcures.org/", "bannerImg": "bafkreidu2kr5ifq7hsz6avuex5ejuhewgkchnlvpn2st4nkekqqtyeu5ce", "createdAt": 1681778901390, "userGithub": "savva007", "credentials": {}, "description": "Crowd Funded Cures is a Web3 charity / Impact DAO (partnered with Rymedi, VitaDAO, Molecule, PsyDAO,  and LabDAO and receiving advisory support from Protocol Labs and the Health Impact Fund) whose mission is to use combine IP-NFTs with Hypercerts to incentivise the funding of clinical trials for low-cost / off-patent therapies (e.g. psychedelics or generic longevity drugs). \n\nBy re-aligning private incentives in the medical industry away from monopoly-priced patented medicines and towards low-cost, open-source therapies, we can use the revenue generated by cost-savings to treat and potentially cure millions of patients and improve global health and well-being, while also driving funding into the DeSci ecosystem. ", "lastUpdated": 0, "projectGithub": "crowdfundedcures", "projectTwitter": "crowdfundedcure"}, "recipient": "0x1Ab75FEA1f27A6dfAfF81b0371AB6d57E112906B"}}